El coronavirus y el futuro que nos espera| Coronavirus and the future that awaits us - 48by7news

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Tuesday, 21 April 2020

El coronavirus y el futuro que nos espera| Coronavirus and the future that awaits us


By BY DONALD G. MCNEIL JR. from NYT en Español https://ift.tt/34VMO6q

Coronavirus is spreading from the largest cities in the United States to its suburbs and has begun to break into the nation's rural regions. The virus is believed to have infected millions of citizens and has claimed the lives of more than 34,000.
However, last week, President Donald Trump proposed guidelines to reopen the economy and suggested that part of the United States would soon return to something akin to normalcy. For several weeks now, the government's outlook on the crisis and our future has been more optimistic than that of its own medical advisers and scientists in general.
The truth is that no one knows for sure where this crisis will take us. More than twenty experts in public health, medicine, epidemiology and history shared their views on the future in detailed interviews. When can we leave our homes? How long will it realistically take before I have a treatment or a vaccine? How will we keep the virus at bay?
Some believe that American ingenuity, once engaged, could produce breakthroughs to ease the burdens. The path to follow depends on factors that are difficult but doable, they said: a carefully phased approach to reopening, widespread testing and surveillance, treatment that works, adequate resources for healthcare providers, and ultimately an effective vaccine.
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Still, it was impossible to avoid bleak forecasts for the coming year. Most experts agree that the scenario Trump has described in his daily press reports is a fantasy: he has said that the confinements will cease soon, that a protection pill is almost at hand, that the stadiums of soccer and restaurants will soon be full.
"A bleak future awaits us," said Harvey V. Fineberg, former president of the National Academy of Medicine.
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He, along with other experts, glimpses a sad population, trapped indoors for months, and, the most vulnerable, perhaps for much longer. They expressed concern that scientists would not be able to find a vaccine soon, that exhausted citizens would ignore the restrictions despite the risks, and that the virus would become part of our lives from now on.
"My optimistic side says that the virus will drop in the summer and that a vaccine will come to the rescue," said William Schaffner, a preventive medicine specialist at Vanderbilt University School of Medicine. "But I am learning to protect myself from my optimistic nature."
Most experts opined that when the crisis ended, the nation and its economy would quickly reactivate. However, it would be inevitable to go through a period of intense pain.
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The exact way in which the pandemic will end will depend, in part, on future advances in medicine. It will also depend on how Americans behave in the meantime. If we scrupulously protect ourselves and our loved ones, most of us will live. If we underestimate the virus , it will find us.
More Americans may die than the White House admits .

Refrigerated trucks were used as mobile morgues on Randall Island in New York. Credit ...Misha Friedman for The New York Times
COVID-19, the disease causing coronavirus, arguably is the leading cause of death in the United States at this time. The virus has killed more than 1,800 Americans almost daily since April 7, and the official figure may be an underestimate of the actual.
In contrast, heart disease typically causes 1,774 deaths a day in the United States, while cancer causes 1,641.
True, the coronavirus curves are stabilizing. In New York, the epicenter of the epidemic, fewer people are being admitted to hospitals and there are fewer COVID-19 patients in intensive care units. The daily total of victims is still discouraging, but it is no longer increasing.
The epidemiological model often cited by the White House , which was produced by the University of Washington Institute for Health Measurement and Assessment, originally predicted that there would be 100,000 to 240,000 deaths by mid-summer. Now that number is 60,000.
While this is encouraging news, it masks some important concerns. The institute's projection runs until August 4, and describes only the first wave of this epidemic. Without a vaccine, the virus is expected to circulate for years and the death toll will increase over time.
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The progress that has been made to date has been thanks to the emergency closure in the country, a situation that cannot continue indefinitely. The "gradual" reopening plan put forth by the White House will undoubtedly increase the number of victims, no matter how carefully implemented. The greatest hope is that deaths are minimal.
Reliable long-term projections of how many Americans will die vary, but they are all bleak. Several experts consulted in March by the Centers for Disease Control and Prevention (CDC) predicted that the virus could eventually reach 48 to 65 percent of Americans, with a death rate. just under 1 percent, and that it would kill an estimated 1.7 million people if nothing were done to prevent the spread.
A model of researchers from Imperial College London, quoted by the American president on March 30, predicted 2.2 million deaths in the country by September, under the same circumstances.
In comparison, around 420,000 Americans died in World War II.
China's limited data is even more disappointing. Its epidemic stopped, for the time being, and virtually all the people infected in the first wave died or recovered.
China has officially reported nearly 83,000 cases and 4,632 deaths , representing a death rate of more than five percent. The Trump administration has questioned the figures , but has not produced more precise ones.
Mortality rates depend largely on how overwhelmed hospitals are and what percentage of cases are tested. According to a report from the Center for Evidence-Based Medicine , China's calculated death rate was 17 percent the first week of January, when Wuhan was in chaos, but only 0.7 percent in late February.
In this country, hospitals in several cities, including New York, reached the limit of chaos. This week, officials in both Wuhan and New York had to adjust their death counts upward when they realized that many people had died at the COVID-19 home, from strokes, heart attacks or other causes, or because ambulances never came for them.
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In dizzying epidemics, far more victims arrive at hospitals or die at home than doctors can test; at the same time, mild or asymptomatic patients are never tested. These two factors distort the true mortality rate in opposite ways. If you don't know how many people are infected, you don't know how deadly a virus is .
Only when tens of thousands of antibody tests are performed will we know how many silent carriers there can be in the United States. The CDC has suggested that it could be 25 percent of those who test positive. Researchers in Iceland say it could be double that .
China is also reviewing its own calculations. In February, a large study concluded that only 1 percent of cases in Wuhan were asymptomatic. New research says perhaps 60 percent were . Our knowledge gaps remain wide enough to make epidemiologists cry.
"All models are just that," said Anthony S. Fauci, science adviser to the White House coronavirus special team. "When you get new data, you make changes to it."
There may be good news hidden in this inconsistency: the virus may be mutating to cause fewer symptoms. In movies, viruses become more deadly. Actually, they generally become less, because asymptomatic strains reach more hosts. Even the 1918 Spanish flu virus finally faded into seasonal H1N1 flu .
At the moment, however, we don't know exactly how transmissible or lethal the virus is. But refrigerated trucks parked outside hospitals tell us everything we need to know: It's much worse than a bad seasonal flu.
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The confinements will end, but with difficulty.

Travelers on the Staten Island CreditFerry ...Misha Friedman for The New York Times
No one knows the exact percentage of Americans who have been infected so far — estimates have ranged from 3 to 10 percent — but at least 300 million of us are likely to remain vulnerable.
Updated 18m ago
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Until a vaccine, or some other protective measure, emerges, epidemiologists agree that there is no way for all of these people to take to the streets safely. If the Americans return by force, everything will seem calm for about three weeks.
Then the emergency rooms will be busy again.
"There is this magical thought that we are all going to resist for a while and then the vaccine we need is going to be available," said Peter J. Hotez, dean of the National School of Tropical Medicine at the Baylor School of Medicine.
In his famous article, “Coronavirus: the hammer and the dance” , published on March 19 in Medium (on March 22 in Spanish ), Tomás Pueyo correctly predicted the national closure, which he referred to as the hammer, and He said it would take us to a new phase, which he called dance, in which essential parts of the economy could be reactivated, such as some schools and some factories with the minimum necessary personnel.
All epidemiological models pose something similar to dance. Everyone assumes that the virus will resurface every time too many carriers emerge and force another emergency shutdown. Then the cycle repeats. On the models, the kill rise and fall curves look like a row of sharp teeth.
Models predict spikes are inevitable, even if stadiums, churches, theaters, bars, and restaurants are closed, everyone arriving from abroad is under 14-day quarantine, and domestic travel is rigorously restricted to prevent areas of high intensity reinfect those of low intensity.
Experts say the tighter the restrictions, the fewer the deaths and the longer the periods between confinements. Most models assume that states will eventually carry out widespread temperature measurements, rapid tests, and contact tracing, as is customary in Asia.
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Even the "Opening America Again" guidelines that Trump unveiled on April 16 have three levels of social distancing, and it is recommended that vulnerable Americans remain hidden. The plan supports testing, isolation, and contact tracing, but does not specify how those measures will be paid for or how long it will take to implement them.
On April 17, none of that prevented the President from contradicting his own message by posting tweets that encouraged protesters in Michigan, Minnesota and Virginia to fight against their state closings.
China did not allow the reopening of Wuhan, Nanjing and other cities until intensive surveillance found zero new cases for 14 consecutive days, the incubation time for the virus . Compared to China or Italy, the United States is still a playground.
Americans can take domestic flights, drive wherever they want, and hit the streets and parks. Despite the restrictions, everyone seems to know someone who discretely organizes children's play dates, roasts in their backyard, or meets people they've met on dating apps.
As a result, the country has registered up to 30,000 new cases of infections a day . "People have to realize that it's not safe to play poker with your face covered in a bandana," said Schaffner.
Even with stringent measures, Asian countries have struggled to keep the virus under control.
China, which has reported 100 new infections a day, recently closed all theaters in the country again. Singapore has closed all non-essential schools and workplaces . Japan recently declared a state of emergency . (South Korea has also had problems , but on Sunday it reported only eight new cases, the first single-digit increase in two months.)
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Resolve to Save Lives, a public health support group led by Thomas R. Frieden , a former CDC director, published a series of detailed and strict criteria on when the economy can reopen and when it should remain closed .
The reopening requires a decrease in cases in a period of 14 days, monitoring of 90 percent of contacts, a halt to contagions among health sector workers, recovery sites for minor cases and many other difficult to achieve objectives.
"We have to reopen the faucet bit by bit, not letting out jets of water all at once," Frieden explained. "This is the time to work so that day comes sooner."
Immunity will become a social advantage.


Officials from Nido de Esperanza, a nonprofit organization, bring food to families with young children in the Washington Heights neighborhood of Manhattan. Credit ...Misha Friedman for The New York Times
Imagine the United States divided into two classes: those who have recovered from coronavirus infection , and could be defined as immune to the virus, and those who remain vulnerable.
"It will be a chilling schism," predicted David Nabarro, special commissioner of the World Health Organization for COVID-19. "Those who have the antibodies will be able to travel and work and the rest will be discriminated against."
Today, people with suspected immunity are in great demand, as they are asked to donate blood with antibodies, and some carry out risky medical work without fear.
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The government will soon have to invent a way to certify who is really immune. An immunoglobulin G (IgG) test, which occurs when immunity is established, could work, said Daniel R. Lucey, a pandemic expert at Georgetown Law School. Many companies are producing them.
Dr. Fauci has said that the White House was discussing certificates such as those proposed in Germany. China uses QR codes on cell phones linked to the owner's personal data, so that others cannot borrow it.
California's adult film industry pioneered a similar idea a decade ago . Actors use a cell phone application to demonstrate that they have tested negative for HIV in the past 14 days, and producers can verify information on a password-protected website.
According to experts' predictions, as homebound Americans see their immune neighbors resume their activities - and perhaps even take the jobs they lost - it's not hard to imagine the enormous temptation to join them through autoinfection. Younger citizens, in particular, are going to reckon that risking serious illness may be a better option than impoverishment and isolation.
"My daughter, who is an economist at Harvard University, always tells me that her age group has to organize COVID-19 parties to develop immunity and help keep the economy going," said Michele Barry , director of the Center. of Global Health Innovation from Stanford University.
It has happened before. In the 1980s, Cuba successfully contained its small AIDS epidemic by brutally imprisoning all who tested positive. Inside, however, residents had their own bungalows, food, medical care, salaries, theater groups, and art classes .
Dozens of homeless young Cubans were infected deliberately through sex or blood injections to gain entry, says Jorge Pérez Ávila, an AIDS specialist who is the Cuban version of Dr. Fauci. Many died before antiretroviral therapy was introduced.
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It would also be a bet for the American youth. The obese and immunocompromised are clearly at risk, but even healthy, skinny youth have died from COVID-19.
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The virus can be kept under control, but only with amplified resources.


A health worker checks her protective gear in a mirror in Central Park, New York. Credit ...Misha Friedman for The New York Times
Experts say the next two years will go by in stumbles. The more immune people return to work, the more the economy will recover.
However, if too many people are infected at the same time, it will be inevitable to carry out new emergency closings. To avoid that, it will be imperative that testing be done across the board.
Fauci said "the virus will tell us" when it is safe. What it means is that, when a national standard of hundreds of thousands of tests performed daily across the country is established, any viral spread can be detected when the percentage of positive results increases.
Detecting fevers on the rise as Kinsa smart thermometers map can give an early signal, Schaffner said.
However, diagnostic testing has been a problem from the beginning . Despite White House claims, doctors and patients continue to complain about its shortages and delays.
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To keep the virus under control, several experts have insisted that the country must start isolating all the sick, even the mildest cases.
In this country, patients who test positive are asked to stay at home but isolated from their families.
Television news has been filled with recovering celebrities, such as CNN's Chris Cuomo, sweating alone in his basement as his wife left the food at the top of the stairs, her children waved, and the dogs waited.
But even Cuomo ended up illustrating why the WHO strongly opposes isolation at home.
On Wednesday, he revealed that his wife had the virus.
"If I were forced to choose just one intervention, it would be the rapid isolation of all cases," said Bruce Aylward, who led the WHO observer team in China .
In China, anyone who tested positive, no matter how mild their symptoms, had to be admitted immediately to a nursing-type hospital, usually installed in a gym or community center equipped with oxygen tanks and CT scanners.
There, they recovered under the supervision of the nurses. That reduced families 'risk, and being with other victims eased some patients' fears. The nurses even gave dance classes and exercises to lift spirits and help victims clear their lungs and maintain muscle tone.
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However, the opinions of the experts were divided regarding this type of facility. Fineberg co-wrote an Opinion article in The New York Times in which he called for mandatory, but "compassionate" quarantine processes.
On the other hand, Marc Lipsitch , an epidemiologist at the TH Chan School of Public Health at Harvard University, opposed the idea, saying: "I do not trust our government to forcibly separate people from their families."
Finally, deleting a virus requires testing all contacts for each known case. But the United States is a long way from that goal.
Someone who works in a restaurant or factory may have tens or even hundreds of contacts. In the Chinese province of Sichuan, for example, each known case had an average of 45 contacts.
The CDC has around 600 contact trackers and, until recently, around 1,600 state and local health departments employed it , primarily to track cases of syphilis and tuberculosis.
China hired and trained 9,000, only in Wuhan . Frieden recently calculated that the United States will need at least 300,000.
There will be no vaccine so soon.


A patient arrives at the New York Presbyterian Hospital in Manhattan. Credit ...Misha Friedman for The New York Times
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Although human clinical trials have already begun on three candidates - two here and one in China - Fauci has repeatedly said that any effort to make a vaccine will take at least a year to 18 months.
All experts familiar with vaccine production agreed that even that time scale is optimistic. Paul Offit, a vaccinologist at the Children's Hospital of Philadelphia, said the record is four years for the mumps vaccine.
The researchers clearly disagreed on what needs to be done to speed up the process. The modern biotechnology techniques using RNA or DNA platforms make it possible to develop vaccine candidates faster than ever.
However, clinical trials take time, in part because there is no way to rush the production of antibodies in the human body.
Likewise, for unclear reasons, some candidate vaccines to combat previous coronaviruses such as SARS have caused an "antibody-dependent boost", making recipients more susceptible to infection, not less. In the past, HIV and dengue vaccines unexpectedly did the same.
Typically, a new vaccine is first tested on fewer than 100 young, healthy volunteers. If it looks safe and produces antibodies, thousands more volunteers - in this case, perhaps the most at-risk workers on the battlefront - get the vaccine or a placebo in what's called a Phase 3 study.
This process can be accelerated with “challenge trials”. Scientists vaccinate a small number of volunteers, wait until they develop antibodies, and then "challenge" them with deliberate infection to see if the vaccine protects them.
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Challenge trials are used only when a disease is fully curable, such as malaria or typhoid fever . Normally, it is ethically unthinkable to challenge subjects with an uncured disease, such as COVID-19.
But in these abnormal times, several experts argued that putting some Americans at high risk for faster results could be more ethical than leaving millions at risk for years.
"Less harm is done if you do a challenge trial on a few people than if you do a Phase 3 trial in thousands," said Lipsitch, who recently published an article advocating challenge trials in the Journal of Infectious Diseases. Almost immediately, he said, volunteers appeared.
Others were deeply uncomfortable with that idea. "I think it's very unethical, but I can't see how we could do it," says Lucey.
The hidden danger of challenge trials, vaccinologists explained, is that they recruit too few volunteers to show if a vaccine creates improvement, which can be a rare but dangerous problem.
"Challenge trials won't give you a safety answer," said Michael T. Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota. "It can be a big problem."
W. Ian Lipkin, a virologist at Columbia University's Mailman School of Public Health, suggested an alternative strategy. Choose at least two candidate vaccines, briefly test them in humans, and do challenge trials in monkeys. Start by having an immediate winner, even as you expand human trials for hidden problems.
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While testing a vaccine is an arduous task, producing hundreds of millions of doses is even more complicated, experts warned.
Most American vaccine plants produce only about five to ten million doses a year, needed for the four million babies who are born and the four million people who turn 65 each year, says R. Gordon Douglas Jr. , former president of Merck's vaccine division.
But if they invent a vaccine, the United States may need 300 million doses, or 600 million, if two vaccinations are needed. And the same number of syringes.
"People have to start thinking big," said Douglas. "With that volume, you should start producing them very soon."
Flu vaccine plants are large, but those that grow vaccines on chicken eggs are not suitable for modern vaccines, which grow in cell broths, he said.
European countries have plants but they will need them for their own citizens. China has a large vaccine industry, which could expand in the coming months. Experts said it could make vaccines for the United States. But captive customers must pay the seller's asking price, and the safety and efficacy standards of some Chinese companies are flawed .
India and Brazil also have large vaccine industries. If the virus moves rapidly through its crowded populations, they may lose millions of citizens but achieve widespread immunity before the United States does. In that case, they may have reserve capacity in their vaccine plants.
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Alternatively, suggested Arthur M. Silverstein, a retired medical historian from the Johns Hopkins School of Medicine, the government could take and sterilize liquor or beer plants that have large fermentation tanks.
"Any distillery could be transformed," he said.
There are likely to be treatments first.


Coronavirus samples to analyze at Mirimus, a medical research company in Brooklyn Credit ...Misha Friedman for The New York Times
In the short term, experts were more optimistic about treatments than about vaccines. Several of them opined that "convalescent plasma" could work.
This basic technique has been used for more than a century: blood is taken from people who have recovered from an illness, then filtered to remove everything except the antibodies. Antibody-rich immunoglobulin is injected into patients.
The obstacle is that there are now relatively few survivors from whom blood can be collected.
In prevalent times, antibodies were "grown" in horses and sheep. But that process was difficult to keep sterile, and animal proteins sometimes triggered allergic reactions.
The modern alternative is monoclonal antibodies. According to experts, these treatment regimens , which recently came very close to ending the Ebola epidemic in eastern Congo, are likely to change the game in the short term.
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The most effective antibodies are chosen, and the genes that produce them are linked into a benign virus that will grow in a cell broth.
But, as with vaccines, the growth and purification of monoclonal antibodies takes time. In theory, with enough production, they could be used not only to save lives but to protect front-line workers.
Antibodies can last for weeks before breaking down, time depends on many factors, Silverstein noted, and they cannot kill the virus that is already hidden inside cells.
Taking a daily preventative pill would be a much better solution, as the pills can be synthesized in factories much faster than vaccines, or antibodies can be developed and purified.
However, even if one were to be invented, production would have to be doubled until it was as ubiquitous as aspirin, so that 300 million Americans could take it daily.
Trump has mentioned hydroxychloroquine and azithromycin so often that his press conferences sound like infomercials . But all experts agree with Dr. Fauci that no decision should be made until clinical trials are completed .
Some recall that in the 1950s inadequate tests for thalidomide caused thousands of children to be born with malformed limbs . More than one study of hydroxychloroquine was stopped after patients who received high doses developed abnormal heart rhythms .
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"I doubt anyone will tolerate high doses, and there are vision problems if it accumulates," said Barry. "But it would be interesting to see if it could work as a drug similar to PrEP," he added, referring to the pills used to prevent HIV.
Others were tougher, especially on Trump's idea of ​​combining chloroquine with azithromycin.
"It is silly," said Luciana Borio, former director of medical preparedness and biodefense at the National Security Council. "I told my family, if you give me the COVID, don't give me that combo."
Chloroquine may protect hospitalized pneumonia patients from lethal cytokine storms because it dampens immune reactions, several doctors said.
However, that doesn't make it useful for preventing infections, as Trump has implied , because it has no known antiviral properties.
Several antivirals — including remdesivir, favipiravir, and baloxavir — are being tested against the coronavirus; the last two are flu drugs.
Trials of various combinations in China will issue results for next month, but they will be small and possibly inconclusive because doctors were left without patients to test. The end dates for most trials in the United States have not yet been established.
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Goodbye to 'America first'.


A church in Washington Heights collects food and other donated goods for Nido de Esperanza, the non-profit organization. Credit ...Misha Friedman for The New York Times
Previously unthinkable social changes have already taken place. Schools and businesses have closed in every state, and tens of millions have applied for unemployment aid. Taxes and mortgage payments were delayed and foreclosures are prohibited.
Stimulus checks, meant to offset the crisis, began hitting checking accounts this week, turning much of the United States, temporarily, into a welfare state. Food banks are opening across the country and large lines have formed.
A public health crisis of this magnitude requires international cooperation on a scale that has not been seen in decades. However, Trump is taking steps to withdraw funding from WHO , the only organization capable of coordinating a response like that.
In addition, it spent most of this year opposing China, which now has the world's most powerful functioning economy and may become the dominant provider of drugs and vaccines. China has used the pandemic to spread its global influence, and says it has shipped medical clothing and equipment to nearly 120 countries.
A major recipient is the United States, through Project Airbridge, an air cargo operation overseen by Trump's son-in-law, Jared Kushner.
Several experts have pointed out that "America first" is not a viable strategy in this world.
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"If President Trump wants to step up public health efforts here, he should look for ways to collaborate with China and let go of the insults," said Nicholas Mulder, economics historian at Cornell University. He has called Kushner's project “Loan-Lease Reverse,” in reference to US military aid to other countries during World War II.
Osterholm was even more direct. "If we alienate the Chinese with our rhetoric, I think they will bite us again," he said.
"What happens if they create the first vaccine? They can choose who to sell it to. Are we first on the list? Why would we be? "
When the pandemic is over, the national recovery may be swift. Mulder noted that the American economy recovered from the two world wars.
Psychological side effects will be more difficult to measure. The isolation and poverty caused by a long period of confinement could increase the rates of domestic violence , depression and suicide .
Even political perspectives can change. At first, the virus hit Democratic cities like Seattle, New York and Detroit hard. But as it spreads across the country, it won't spare anyone.
Even voters in Republican states who don't blame Trump for America's lack of preparedness or limiting access to health insurance can change their minds if they see friends and family die.
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In one of the most provocative analyzes in his follow-up article, " Coronavirus: Out of Many, One, " Pueyo analyzed Medicare and census data on age and obesity in states that recently resisted confinement and in counties. who voted for Republicans in 2016.
He calculated that those voters could be 30 percent more likely to die from the virus.
Mulder mentioned that in the periods after both world wars, society and income became more equitable. Funds created for veterans and widows pensions fostered social safety nets, measures such as the Veterans Aid Act or GI (to finance demobilized soldier studies) and mortgage loans from the Department of Veterans Affairs were taken. , unions strengthened, and budget benefits for the wealthy waned.
Experts suggested that if a vaccine does save lives, many Americans may be more confident in conventional medicine and more receptive to science in general, including on issues like climate change.
The clear skies that have shone in American cities during this era of confinement could even become permanent.


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